Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely
نویسندگان
چکیده
منابع مشابه
Apelin-APJ signaling in retinal angiogenesis.
The G protein–coupled receptor (GPCR) APJ (X-msr, angiotensin receptor like 1b) was cloned in several laboratories by homology screening, with the goal of identifying new members of this class of cell surface receptor.1 This gene attracted attention because of its sequence similarity to the important angiotensin II type 1 receptor and its highly restricted pattern of expression in endothelial c...
متن کاملThe apelin-APJ system induces tumor arteriogenesis in hepatocellular carcinoma.
AIM The apelin-APJ system regulates angiogenesis, and is overexpressed in several types of cancer. The aim of this study was to clarify the role of the apelin-APJ system in the angiogenesis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS Expressions of angiogenic factors and vascular markers were investigated in specimens from 90 HCC patients. A subcutaneous HCC tumor mouse model was...
متن کاملThe Apelin-APJ System in the Evolution of Heart Failure
Heart failure is a chronic, progressive disease in which the overexpression of biologically active molecules and neurohomonal activation are the key factors of the evolution and natural history. The apelin-APJ system is a newly discovered molecular pathway and the RAAS counterbalance is its principal effect. The apelin is a potent inotrope, vasodilator and diuretic with crucial cardioprotective...
متن کاملApelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.
In addition to the CCR5 and CXCR4 chemokine receptors, a subset of primary human immunodeficiency virus type 1 (HIV-1) isolates can also use the seven-transmembrane-domain receptor APJ as a coreceptor. A previously identified ligand of APJ, apelin, specifically inhibited the entry of primary T-tropic and dualtropic HIV-1 isolates from different clades into cells expressing CD4 and APJ. Analysis...
متن کاملApelin/APJ system: A key therapeutic target for liver disease
Apelin, a new bioactive peptide, was identified as an endogenous ligand for APJ (Angiotensin II receptor-like 1). Apelin and its receptor have an abundant distribution in central nervous system and peripheral tissues, including liver. Apelin/APJ has diverse physiological and pathological effects, including regulation of cardiovascular function, angiogenesis, fluid homeostasis and so on. Apelin/...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 2011
ISSN: 0916-9636,1348-4214
DOI: 10.1038/hr.2011.19